Category: Breaking News
Discovery of alpha-glucosidase inhibitory peptides from hemp seed protein via integrated peptidomics and molecular dynamics simulation
The escalating prevalence of type 2 diabetes mellitus necessitates the development of safe and effective α-glucosidase inhibitors from natural food sources. This study employed an integrated strategy combining peptidomics, computational screening, and molecular dynamics (MD) simulation to discover novel α-glucosidase inhibitory peptides from hemp seed protein hydrolysates. Nano-LC-MS/MS identified 4875 unique peptides, predominantly short-chain sequences (...
Toward sustainable plant-based foods: Physicochemical and nutritional evaluation of hemp seed tofu-like gel prepared with various coagulants
Global population growth and climate change intensify demand for sustainable protein sources. Defatted hemp seed (DHS), a protein-rich by-product of hemp oil extraction, remains underutilized in food applications. In this study, hemp seed tofu-like gels (HSTG) were produced from DHS through heat-induced coagulation using five food-grade coagulants: MgCl₂, CaCl₂, CaSO₄, glucono-δ-lactone (GDL), and transglutaminase (TGase). The composition-structure-function relationships of the resulting gels...
Cavitation jet treatment-assisted glycosylation of hemp seed protein: Structural regulation and emulsion stability
This study employed cavitation jet treatment to facilitate the effective glycosylation of hemp seed protein (HSP) with chitosan (CS). Initially, the treatment disrupted intra- and inter-molecular hydrogen bonds, inducing HSP structural unfolding. This critical conformational transition exposed internal reactive amino groups, enabling them to interact with CS carbonyl groups and achieving a maximum grafting degree of 34.54%. Consequently, the secondary structure of HSP was reorganized from an...
Antioxidant and Bioactive Properties of a Biopolymeric Matrix from Hemp Seed Waste: An Application as a Scavenger of Reactive Oxygen Species in Viscosupplements
A biopolymer-enriched matrix from hempseed waste (BMH extract) was extracted using hot water and characterized. Biochemical assays pointed out that the BMH extract contained carbohydrates, proteins, and phenols in different percentages, while NMR spectroscopy and monosaccharide analysis revealed starch as the dominant polysaccharide. The BMH extract showed biocompatibility and a stimulatory effect on fibroblast viability. Its antioxidant activity in biochemical and cellular assays was comparable...
Hemp Seed-Derived Vesicle-like Nanoparticles Modulate Dermal Collagen Homeostasis and Attenuate UVB-Induced Photoaging-Related Responses
Plant-derived extracellular vesicle-like nanoparticles (EVNPs) have emerged as bioactive nanomaterials with potential applications in skin biology; however, their isolation from complex plant matrices and their integrated biological effects remain insufficiently characterized. In this study, hemp seed-derived vesicle-like nanoparticles (hs- extracellular VLNPs) were isolated using a multi-step workflow combining pre-clarification, sequential filtration, electrokinetic capture, and tangential...
Nutritional Contribution and Bioactive Properties of Romanian Monoecious Hemp Seed (Cannabis sativa L.) Varieties for Potential Food Applications
Hemp seeds (Cannabis sativa L.) are nutrient-dense, plant-based food ingredients. However, cultivar-related variability in its compositional profile remains insufficiently characterized for Romanian varieties. This study evaluated six Romanian monoecious hemp seed varieties (Dacia Secuieni, Secuieni Jubileu, Ratza, Zenit, Succesiv, and Olivia), for their potential food applications. Dacia Secuieni, Secuieni Jubileu, Ratza, and Olivia showed the highest crude protein content (24.79-25.57%)...
Hypoglycemic Effect of Hemp Seed Cake Protein Hydrolysates in Streptozotocin-Induced Diabetic Mice
The potential of plant-based bioactive peptides to be used as an alternative or complementary therapy for the safe management of metabolic diseases such as diabetes is garnering increasing attention. In this in vivo study, the hypoglycemic effect of bromelain hydrolysates of hemp seed cake protein is analyzed in streptozotocin-induced diabetic mice. The results demonstrate that treatment of mice with the hydrolysate at a dose of 200 mg/kg/day for 4 weeks leads to a significant decrease in blood...
Structure and functional properties of Dendrobium officinale polysaccharide-hemp seed protein gels for dysphagia diets as regulated by alkali concentration and temperature
Dysphagia is highly prevalent among older adults and increases the risks of malnutrition, dehydration, and aspiration pneumonia, highlighting the need for safe and nutritionally adequate texture-modified foods. Polysaccharide-protein gels are promising candidates for this purpose, but precise control of their rheological properties and structural stability remains challenging. Here, we systematically investigated how alkali concentration (Na(2)CO(3), 0.5-2.5%, w/v) and thermal treatment (25-85...
Modification of the existing maximum residue levels for propyzamide in oilseeds and honey
In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Corteva submitted a request to the competent national authority in Sweden to modify the existing maximum residue levels (MRLs) for the active substance propyzamide in oilseed rape, mustard seeds, gold of pleasure seeds, linseeds, sesame seeds, hemp seeds, borage seeds and honey. The data submitted in support of the request were found to be sufficient to derive MRL proposals for all the crops under assessment. Adequate...